Novel magnesium alloy Mg-2La caused no cytotoxic effects on cells in physiological conditions

authored by

Andreas Weizbauer, Jan Marten Seitz, Peter Werle, Jan Hegermann, Elmar Willbold, Rainer Eifler, Henning Windhagen, Janin Reifenrath, Hazibullah Waizy

Abstract

Using several different in vitro assays, a new biodegradable magnesium alloy Mg-2La, composed of 98% magnesium and 2% lanthanum, was investigated as a possible implant material for biomedical applications. An in vitro cytotoxicity test, according to EN ISO 10993-5/12, with L929 and human osteoblastic cells identified no toxic effects on cell viability at physiological concentrations (at 50% dilutions and higher). The metabolic activity of human osteoblasts in the 100% extract was decreased to < 70% and was therefore rated as cytotoxic. The degradation rates of Mg-2La were evaluated in phosphate buffered saline and four different cell culture media. The degradation rates were shown to be influenced by the composition of the solution, and the addition of fetal bovine serum slightly accelerated the corrosive process. The results of these in vitro experiments suggest that Mg-2La is a promising candidate for use as an orthopedic implant material.

Organisation(s)

High Voltage Engineering and Asset Management Section (Schering Institute)
Institute of Materials Science

External Organisation(s)

Hannover Medical School (MHH)
University of Veterinary Medicine of Hannover, Foundation

Type

Article

Journal

Materials Science and Engineering C

Volume

41

Pages

267-273

No. of pages

7

ISSN

0928-4931

Publication date

01.08.2014

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

General Materials Science, Condensed Matter Physics, Mechanics of Materials, Mechanical Engineering

Electronic version(s)

https://doi.org/10.1016/j.msec.2014.04.063 (Access: Unknown)